Search WWW Search care4lupus.blogspot.com

Azathioprine-Skin Cancer Link Not Found in Lupus

Saturday, November 05, 2005

Azathioprine-Skin Cancer Link Not Found in Lupus

Scientists in Great Britain have studied how the anti-rejection drug azathioprine might increase the risk of skin cancer among transplant patients. The in vitro (test tube) study showed that azathioprine, which also is used to treat lupus, accumulates in a patient's DNA and makes cells more sensitive to ultraviolet (UV) light. When patients are exposed to low doses of UV light, the drug alters the DNA, triggering mutations in cells.

Themodest increase in risk of cancer among transplant patients taking azathioprine along with other immune suppressing drugs is widely known. However, an epidemiological study of cancers and lupus has not discovered a parallel increase in cancer among lupus patients taking azathioprine. Since lupus patients are advised to wear sun block and avoid sun exposure anyway, there is no reason to discontinue use of the drug if the risk/benefit ratio warrants its use. Lupus patients should advise their doctor if they notice any unusual skin lesions as part of their regular disease-monitoring activities.

To read a news report on this study go to: http://news.bbc.co.uk/2/hi/health/4248356.stm

Blogged on 5:31 PM

|

~~~